Machine Learning Scientist

pAt Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. /p h3The Position /h3 pAI Biology Translation (AIBT) develops and applies state-of-the-art artificial intelligence to accelerate biomedical discovery across Research and Early Development in Genentech Roche.

We combine advances in foundation models, multimodal machine learning, and large-scale biological data to advance target discovery, disease understanding, biomarker development, and translational science. /p pWe are seeking a (Senior) ML Scientist with deep expertise in modern machine learning to lead the development and application of next-generation AI technologies for designing DNA and RNA sequences for nucleic acid-based medicines. We work closely with stakeholders in Cell Therapy, Gene Therapy, and Vaccine Oncology on diverse projects, ranging from platform development for lab-in-the-loop refinement of sequence designs to lead optimization for portfolio projects.

Representative work includes designing regulatory elements to confer cell-type-specific transcription and engineering synonymous coding sequences to enhance translational efficiency. /p pAs a Scientist / Senior Scientist, you will directly lead sequence design campaigns, translating biological questions into predictive and generative models, and driving iterative sequence optimization in close collaboration with wet-lab experimentalists. /p h3The Opportunity /h3 ul liBuild, train, and fine-tune machine learning algorithms to optimize nucleic acid-based medicines for active portfolio projects /li liDesign candidate sequence libraries for lab-in-the-loop optimization cycles, analyze experimental readouts (e.g., MPRA, NGS), and iteratively update designs /li liCollaborate cross-functionally with wet-lab scientists and project leads to understand therapeutic constraints and tailor design

algorithms accordingly /li liPresent technical findings, candidate designs, and model performance metrics to cross-functional team members and stakeholders /li liStay current with advancements in biological sequence modeling and nucleic acid therapeutics to bring state-of-the-art methods into our pipeline /li liContribute to scientific publications /li /ul h3Who You Are /h3 ul liPh.D. in a quantitative discipline (Bioinformatics, Computational Biology, Computer Science, Machine learning, or a related field) with 0-4 years of post-doctoral or industry experience /li liDemonstrated research impact at the interface of machine learning and molecular biology, evidenced by publications in top-tier journals or ML conferences /li liStrong Python programming skills and proficiency in deep learning frameworks such as PyTorch /li liHands-on experience developing, training, or fine-tuning

sequence-to-function models for biological molecules (preferably DNA/RNA) /li liExcellent communication skills in English, with the ability to speak to both computational and experimental scientists /li /ul h3Preferred Qualifications /h3 ul liPrior experience applying machine learning in a biotech, pharma, or industry setting /li liDomain knowledge in nucleic acid-based therapeutics (e.g., mRNA design, AAV capsid/promoter engineering, cell therapy vectors) /li liExperience with advanced ML frameworks relevant to sequence design, such as generative modeling (diffusion, autoregressive sequence models, masked language models), active learning, model interpretability, or uncertainty quantification /li liFamiliarity with high-throughput functional genomics data processing (e.g., MPRA, RNA-seq, ribosome profiling) /li /ul h3About AI Biology Translation (AIBT) /h3 pAI Biology Translation (AIBT)

is part of the Computational Sciences Center of Excellence (CS-CoE). AIBT advances the development and application of cutting-edge artificial intelligence to accelerate biomedical discovery and translational science. By integrating expertise in machine learning, computational biology, and software engineering, AIBT develops AI capabilities that enable researchers to generate new biological insights, accelerate scientific decision-making, and transform research across Genentech Roche. /p h3Who we are /h3 pA healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products.

We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. /p pLet’s build a healthier future, together. /p pbRoche is an Equal Opportunity Employer. /b /p